Thursday, 23 March 2017

Immninisable Diseases Unit - EPI DIVISION STUDIES

Estimating the population immunity to polio among Ugandan adults and estimating the sero-prevalence to measles and rubella among Ugandan women - PLANNED

Polio, measles, and rubella are important vaccine-preventable diseases for which this study seeks to characterize the population susceptibility to each in Uganda. One objective is to estimate population immunity to polio by region, age, and sex by measuring neutralizing antibodies against poliovirus serotypes (P1, P2, and P3) in 3000 serum samples collected during the 2010 Uganda AIDS Indictor Survey (UAIS) using polio neutralization assays. The other objectives are to estimate sero-prevalence, as a surrogate for population immunity, to measles and rubella by measuring measles-specific and rubella-specific IgG antibodies in 1000 serum samples collected among pregnant mothers during the 2010 Antenatal care (ANC) sero-prevalence survey using commercial IgG ELISA kits with confirmatory testing of selected measles negative/indeterminate samples by plaque reduction neutralization testing. By estimating population immunity to polio, measles, and rubella through measuring seropositivity among adults, susceptible populations might be identified and preventive vaccination efforts planned to close immunity gaps in targeted age groups. Characterizing population immunity to polio in a variety of settings among adults, particularly in areas at high-risk of importations will help to better target global prevention efforts. Understanding rubella susceptibility in pregnant women will provide practical knowledge towards elucidating the burden of disease and need for introduction of rubella vaccine, and how that introduction might be combined with accelerated measles vaccination activities.

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